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KMID : 0356720040200040205
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Journal of the Korean Society of Coloproctology
2004 Volume.20 No. 4 p.205 ~ p.210
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c-Met Expression in Colorectal Carcinoma and Adenomas: Correlation with Clinicopathologic Parameters
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Kim Jin
Kim Chung-Yun
Lee Won-Jin
Cho Seong-Jin
Min Byung-Wook
Um Jun-Won
Cho Min-Young
Seo Seong-Ok
Moon Hong-Young
Whang Jeong-Woong
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Abstract
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Purpose: Hepatocyte growth factor (HGF) stimulates proliferation, migration, and morphogenesis of epithelial cells by specifically binding to its receptor c-met. Abnomalities of the c-met oncogene have been studied in cancers of many organs including thyroid, lung, pancreas, and stomach. However, little is known about the clinical significance of c-met oncogene abnormalities in colorectal carcinomas. In this study, we investigated over- expression of the c-met protein in colorectal adenomas and adenocarcinomas, and analyzed the clinicopathologic significance of this over-expression.
Methods: Expression of the c-met protein localized in colorectal adenoma and adenocarcinoma tissues was analyzed by using immunohistochemistry. The results were compared with clinicopathologic parameters to find clinical correlation.
Results: c-met protein was detected in 42.5% (17/40) of colorectal cancers and in 10.0% (4/40) of colorectal adenomas (P= 0.001). In colorectal cancer, the proportion of expression of c-met protein was 0% (0/40) in stage I, 47.6% (10/40) in stage II, 53.8% (7/40) in stage III and, 0% (0/40) in stage IV. c-met protein expression was 18.8% (3/40) in tumors with invasion into the muscularis propria (MP), and 58.3% (14/40) in tumors with invasion beyond the MP. The depth of tumor invasion was a statistically significant factor (P=0.022) for c-met expression.
Conclusions: The c-met protein expression was related to the depth of invasion of colorectal cancer and showed a significant difference in its rate of expression between adenoma and adenocarcinomas. J Korean Soc Coloproctol 2004;20:205-210
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KEYWORD
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Proto-oncogene protein c-met, Colorectal neoplasms, Adenoma
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